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Efficacy and Safety of Different Dosages of Praziquantel for the Treatment of Schistosoma Japonicum:A Systematic Review and Meta-Analysis
Schistosomiasis Japonicum Praziquantel Meta-Analysis
2015/10/15
Background: Praziquantel, an antischistosomal compound, is used as first-line drug for chemotherapy of Schistosoma japonicum since 1984. In this article, we conducted a systematic review and mete-anal...
手足口病患儿早期抗炎-促炎机制及免疫功能变化的研究
细胞因子 全身炎症反应综合征 代偿性抗炎反应综合征
2014/11/14
探讨手足口病(HFMD)患儿的肿瘤坏死因子(TNF)α、白细胞介素(IL)-6、IL-10及免疫功能的变化。 方法 选择2012年5月至10月于山东省即墨市人民医院儿科手足口病门诊就诊及住院治疗的首次确诊为HFMD患儿56例为研究对象,并将其纳入实验组。随机选择同期于本院行健康体检的20例健康儿童纳入对照组。两组儿童的性别、年龄等一般临床资料比较,差异无统计学意义(P>0.05)。检测两组儿童免...
Successful Treatment of Pemphigus Vulgaris With the Extensive Mucocutaneous Lesions in an Elderly Patient
Pemphigus Aged Therapeutics
2015/10/13
Introduction: Pemphigus vulgaris (PV) is a chronic and infrequent autoimmune mucocutaneous disease that is characterized by the loose blisters and erosions on the skin and mucous membrane. Middle-aged...
负性共刺激分子在脓毒症中的免疫调节
负性共刺激分子 脓毒症中 免疫调节
2014/10/17
脓毒症 (sepsis) 是临床常见的危重疾病, 其发病率及病死率均很高。在脓毒症的发生发展过程中, 严重的免疫抑制是导致脓毒症患者病情恶化的重要因素。细胞毒 T 淋巴细胞相关抗原 4 (CTLA-4) 、 程序性死亡因子 1 (PD-1) 及 B、T 淋巴细胞因子 (BTLA) 等负性共刺激分子可负性调节细胞的增殖、分化及凋亡, 可能在脓毒症免疫紊乱中发挥重要作用。现根据国内外的研究进展,对脓毒...
探讨痛风性关节炎(gouty arthritis,GA)患者外周血单个核细胞(peripheral blood mononuclear cells,PBMCs)中核苷酸结合寡聚化结构域样受体3(nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing, NLRP3)炎性体基因...
IgG4相关性疾病的发病机制及进展
免疫球蛋白G IgG4相关性疾病
2014/9/1
IgG4相关性疾病是一种多器官、多系统受累的新被认识的疾病,其主要特征为:血清IgG4水平升高和病变组织IgG4+浆细胞浸润。IgG4相关性疾病临床表现复杂多样,可涉及多个学科,临床易漏诊和误诊。本篇综述将从基因遗传、感染和分子模拟、免疫学角度等多方面阐述IgG4相关性疾病的发病机制,以加深临床医师对该病的了解。
利用TrueBlot 抗体改善内源性蛋白的免疫沉淀/ 免疫印迹分析
免疫沉淀 免疫印迹 TrueBlot 抗体
2014/8/13
改善内源性蛋白的免疫沉淀/ 免疫印迹分析中免疫沉淀抗体对免疫印迹检测带来的干扰。方法:收集培养的Hela 细胞或FLAG 标记的S5b 基因表达载体转染的Hela 细胞,制备全细胞裂解液,分别加入特异性抗体沉淀S5b 并洗脱,收集免疫复合物,通过SDS-PAGE 分离,采用HRP 标记的TrueBlot 抗体或常规二抗,对S5b 及其相互作用蛋白(Rpt1 和Rpt2) 进行免疫印迹检测。结果:得...
hCaMKⅡNα对结肠肿瘤分泌免疫抑制因子的抑制作用
LoVo细胞 SW620细胞 HT29细胞 VEGF IL-8 IL-10
2014/7/16
探讨钙离子/钙调素依赖性蛋白激酶Ⅱ抑制蛋白α(human calcium/calmodulin-dependent protein kinase Ⅱ inhibitory alpha,hCaMKⅡNα)对结肠肿瘤细胞分泌免疫抑制因子的影响及其作用机制。方法:将hCaMKⅡNα基因表达载体(pKⅡNα)或siRNA(si-KⅡNα)转染至结肠肿瘤细胞(LoVo细胞、SW620细胞和HT29细胞),形...
Tim-3 在不明原因复发性流产患者绒毛和蜕膜组织中的表达
不明原因复发性流产 绒毛 蜕膜 免疫组织化学
2014/10/24
探讨Tim-3在不明原因复发性流产患者绒毛和蜕膜组织中的表达。方法 选取2012年3月至2013年6月在临沂市妇幼保健院就诊的不明原因复发性流产患者30例(病例组),同期正常妊娠(孕周6~12 w)进行人工流产者30例(对照组),应用免疫组织化学染色技术观察Tim-3在两组绒毛和蜕膜组织中的表达。结果 两组Tim-3蛋白主要表达于绒毛的滋养层细胞、合体滋养层细胞的细胞质和绒毛间质内,以及蜕膜组织腺...
Immunological Tolerance: Therapeutic Induction
免疫耐受诱导 Immunological Tolerance: Therapeutic Induction
2014/6/24
Protection from the development of autoimmune diseases and acceptance of transplanted organs are due to effective tolerance to self-antigens and alloantigens, respectively. Various immunological strat...
Immunological tolerance refers to a reduction or complete inhibition of the ability of an individual to mount a specific immune response upon immunization.
Immunodeficiency, Primary: Affecting the Adaptive Immune System
免疫缺陷 Immunodeficiency, Primary: Affecting the Adaptive Immune System
2014/6/24
Primary immunodeficiency (PID) is an intrinsic defect of the immune system. Patients with PID have increased susceptibility to recurrent and persistent infections, but other symptoms are also common.
Chemotaxis is defined as the unidirectional movement of a cell in response to a chemical gradient in the direction from a low to a high concentration of chemoattractant.
A variety of cell types are important components of the immune system. They constitute some of the body’s main defences against infection.
Immunoregulation
Immunoregulation 免疫调节
2014/6/24
The immune system serves essential functions in protection from numerous pathogenic organisms and, in general, is not harmful to the host. The process by which the immune response is restrained or con...