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Analysis of metal ion binding to DNA in regulating metallothionein-IIA gene expression
metallothionein metal responsive elements metal ions binding DNA bending
2009/4/1
The mammalian metallothioneins (MT) are effectively induced in response to the various heavy metal ions. The inductions of these genes are mainly based on the transcriptional activation and the metal ...
Effects of metallothionein on the concentrations of trace elements in mice under the stress conditions
Metallothionein Stress Trace elements Zinc Manganese Molybdenum
2009/4/1
Our object of this study was to investigate the effects of metallothionein, metal binding protein, on the change of the tissue distribution of essential metals by restraint stress. Wild-type and MT-nu...
Effects to amount of metallothionein and mRNA in testis by cadmium injection and oral administration to male rats
Cadmium intake Metallothionein Cadmium toxicity Testicular damage Gene expression
2009/4/1
Male Wistar rats were given cadmium by intraperitoneal (ip) injection (1mgCd/kg). Other male Wistar rats were given Cd by oral administration at a dose of 0, 1, 2, and 5 mgCd/kg/day. All rats were sla...
Metallothionein-IIA gene transcription in cisplatin-resistant cells and its metal-signalling mechanism by Cu(II) ion
Metallothionein-IIA gene transcription cisplatin-resistant cells metal-signalling mechanism
2009/4/1
Increased metallothionein (MT)-IIA transcription is found in some cells with acquired resistance to cisplatin (CDDP). It is also known that mammalian MT is induced by copper. MT induction by TPA (12-O...
Modulation of cytokine expression by zinc and metallothionein
zinc metallothionein cytokine IL-1 IL-6 M-CSF TNF
2009/4/1
A metal chelator diethylenetriaminepentaacetic acid (DTPA) has been reported to inhibits replication of human cytomegalovirus (hCMV). In the investigation of the mechanism of DTPA-induced antiviral ef...
Effects of short-term methylmercury exposure on metallothionein mRNA levels in the testis and epididymis of the rat
short-term methylmercury metallothionein mRNA rat
2009/2/18
Methylmercury (MeHg) is a widespread environmental contaminant that causes reproductive dysfunction in men. Metallothioneins (MTs) are low-molecular-weight proteins that can bind heavy metals and pr...
Zinc and Metallothionein Levels and Expression of Zinc Transporters in Androgen-Independent Subline of LNCaP Cells
Hormone-refractory metallothionein ZnT1 ZnT3
2008/12/22
Zinc levels in the prostate have been reported to be associated with the development and progression of malignant prostate cells. To investigate the reason why the zinc content decreases during th...
Induction of liver metallothionein contribute to the developmental toxicity of valproic acid in rat
Teratogenicity Valproic acid Zinc Metallothionein
2010/2/5
There is an increased risk of neural tube defects and axial skeletal malformations among infants born by mothers who had received Valproic acid...The aim of the present study is, if administration of ...