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The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro
The anti-influenza virus drug arbidol efficient inhibitor SARS-CoV-2 in vitro
2020/6/11
Since December 2019, a novel disease COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread to over 200 countries and infected over 1.50 million people includin...
Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion
Inhibition SARS-CoV-2 Pan-Coronavirus Fusion Inhibitor Targeting High Capacity Mediate Membrane Fusion
2020/6/12
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To develop specific anti-coronavirus therapeuti...
Orlistat, a lipase inhibitor, for weight maintenance after conventional dieting: a 1-y study
Obesity orlistat lipase inhibition
2016/5/31
Long-term maintenance of weight loss remains a
therapeutic challenge in obesity treatment.
Comparing the Efficacy of Bupropion and Amantadine on Sexual Dysfunction Induced by a Selective Serotonin Reuptake Inhibitor
SSRIs Sexual Dysfunction Bupropion Amantadine
2015/12/29
Background: Antidepressant-induced sexual dysfunction (SD) is a common problem, associated with a significant risk of non-adherence. Selective Serotonin Reuptake Inhibitors (SSRIs) are associated with...
An inhibitor of the mitotic kinase, MPS1, is selective towards pancreatic cancer cells
CIN70 MPS1 kinase inhibitor pancreatic cancer
2015/5/21
The abysmal five year pancreatic cancer survival rate of less than 6% highlights the need for new treatments for this deadly malignancy. Cytotoxic drugs normally target rapidly dividing cancer cells b...
Synthesis and Mechanistic Studies of a Novel Homoisoflavanone Inhibitor of Endothelial Cell Growth
Endothelial Cell Growth Synthesis and Mechanistic
2014/11/25
Preventing pathological ocular angiogenesis is key to treating retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration. At present there is no small molecule drug on the ...
A Multicenter Study on Expressions of Vascular Endothelial Growth Factor, Matrix Metallopeptidase-9 and Tissue Inhibitor of Metalloproteinase-2 in Oral and Maxillofacial Squamous Cell Carcinoma
Oral Surgical Procedures Carcinoma Squamous Cell
2015/10/12
Background:: Vascular endothelial growth factor (VEGF), matrix metallopeptidase-9 (MMP-9) and tissue inhibitor of metalloproteinase-2 (TIMP-2) are potential markers of oral and maxillofacial squamous ...
Successful Management of Total Knee Replacement in a High Responder Hemophilia Patient With a History of Inhibitor
Orthopedics Hemophilia A Hemophilia B Inhibitor
2015/9/29
The development of inhibitors against administered clotting factors may render replacement therapy ineffective for some hemophilia patients. Such patients are therefore at the highest risk of developi...
Rock1 Inhibitor Abrogates Chronic Rejection in Rat Cardiac Model System
Chronic Rejection Transplantation ROCK1 RhoA T Cell
2013/1/31
Background: We have shown previously that the abrogation of acute and chronic rejection of rat cardiac allografts occurs through the down-regulation of RhoA pathway and involves the changes in RhoA ki...
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
The c-MYC oncoprotein NAMPT enzyme SIRT1-inhibitor DBC1 SIRT1 deacetylase
2012/2/1
Silent information regulator 1 (SIRT1) represents an NAD+-dependent deacetylase that inhibits proapoptotic factors including p53. Here we determined whether SIRT1 is downstream of the prototypic c-MYC...
Comparison of Oral and Intravenous Proton Pump Inhibitor on Patients with High Risk Bleeding Peptic Ulcers: A Prospective, Randomized, Controlled Clinical Trial
Proton pump inhibitor Bleeding Peptic ulce
2015/9/23
Background: Proton pump inhibitors (PPIs) decrease the rate of rebleeding following endoscopic hemostatic therapy in patients with bleeding peptic ulcers. This study compares the efficacy of oral omep...
The association of TAFI (Thrombin-activatable fibrinolysis inhibitor) with insulin resistance and components of metabolic syndrome in patients with metabolic syndrome
Metabolic syndrome TAFI insulin resistance
2010/12/21
To investigate the association of TAFI with components of metabolic syndrome and insulin resistance in patients with metabolic syndrome. Materials and methods: Patients between 20 and 70 years of age,...
The association of TAFI (Thrombin-activatable fibrinolysis inhibitor) with insulin resistance and components of metabolic syndrome in patients with metabolic syndrome
Metabolic syndrome TAFI insulin resistance
2010/11/22
To investigate the association of TAFI with components of metabolic syndrome and insulin resistance in patients with metabolic syndrome. Materials and methods: Patients between 20 and 70 years of age,...
Clostridium Difficile Associated Diarrhoea and the Rela-tionship to Antibiotic Prescription Practices and Proton Pump Inhibitor Use in Elderly Wards
Clostridium Difficile Diarrhoea Antibiotic Proton pump inhibitor Elderly
2015/9/22
Background: Clostridium difficile-associated diarrhoea (CDAD) is associated with an increased morbidity and mortality rate in elderly population. As in one of the north London hospitals, an increase i...
Potential of a COX2 inhibitor in lowering chemotherapyinduced neutropenia
Breast neoplasms Chemotherapy Cyclooxygenase-2 Neutropenia
2012/7/13
Objective This study was initially designed to evaluate the effect of celecoxib on the regimen of 5fluorouracil, epirubicin, and cyclophosphamide (FEC) combination, followed by docetaxel (T) in neoad...