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异种胰岛移植联合应用免疫抑制剂FK506和LEF的实验研究
异种胰岛移植 免疫抑制剂 FK506 LEF
2009/7/28
目的: 探讨亚治疗剂量免疫抑制剂他克莫司(FK506)和来氟米特(leflunomide，LEF)联和应用预防猪对鼠异种胰岛移植排斥反应的效果.方法: 实验分对照组、FK506组、LEF组、FK506+LEF组，每组7只糖尿病大鼠，将分离纯化获得的新鲜成年猪胰岛(adult pig islets，APIs)立即植入四氧嘧啶诱导的糖尿病大鼠肾被膜下(20 000 IEQ/kg)，通过血糖测定、病理组...
Inhibitory effects of pemirolast potassium and FK506 on degranulation and IL-8 production of eosinophils
anti-allergic drug cytokine eosinophil degranulation
2010/11/26
Eosinophils are the key effector cells for allergic inflammation. In order to clarify drugs which can regulate eosinophil function, we investigated the direct effect of pemirolast potassium (anti-alle...