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Effect of MK-906, a specific 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates in normal men
MK-906 5 alpha-reductase inhibitor serum androgens androgen conjugates normal men
2009/2/23
To determine the hormonal effects of MK-906, an orally active 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates, 12 healthy men were given 10, 20, 50, and 100 mg MK-906 2 weeks a...
Treatment of men with idiopathic oligozoospermic infertility using the aromatase inhibitor, testolactone. Results of a double-blinded, randomized, placebo-controlled trial with crossover
men idiopathic oligozoospermic infertility aromatase inhibitor testolactone
2009/2/23
The hypothesis that increased estradiol production may be the cause of impaired spermatogenesis in infertile men with idiopathic oligozoospermia was tested by administering the aromatase inhibitor...
Purification and characterization of a sperm motility inhibitor in human seminal plasma
sperm motility inhibitor human seminal plasma
2009/2/23
A sperm motility inhibitor from human seminal plasma was purified and characterized. The purification procedure includes dialysis, ion exchange chromatography on SP-Sephadex C-25 and adsorption chro...
Regulation of gonadotropin secretion in the male: effect of an aromatization inhibitor in estradiol-implanted, orchidectomized dogs
gonadotropins testosterone estradiol aromatase aminoglutethim
2009/2/23
Testosterone is aromatized to estradiol in both peripheral tissues and the central nervous system. Various authors have suggested that this conversion in the male may be prerequisite for the regulat...
The presence of a motility inhibitor within spermatozoa may explain the poor sperm motility of some infertile men
motility inhibitor spermatozoa poor sperm motility infertile men
2009/2/23
The presence of motility inhibitors in seminal plasma and within spermatozoa from control and infertile men with poor sperm motility was investigated using demembranated reactivated human spermatozo...
Low molecular weight FSH binding inhibitor in bovine testis
Low molecular weight FSH bovine testis
2009/2/23
Purification of low Mr (less than 5000) inhibitors of FSH binding to receptors has been hampered by their low concentration in tissue extracts and physiologic fluids. The calf testis represents an a...
Origin of a motility inhibitor within the male reproductive tract
motility inhibitor male reproductive tract
2009/2/20
Seminal plasma contains a motility inhibitor of demembranated reactivated spermatozoa. We investigated its origin within the reproductive tract. The highest level of inhibitor was detected in semina...
Occurrence of DOPA/5-HTP Decarboxylase in Human Seminal Plasma：Kinetic Parameters and Demonstration of a Naturally Occurring Inhibitor of the Enzyme
DOPA/5-HTP decarboxylase human seminal plasma biogenic amines
2009/2/18
The authors found that DOPA/5-HTP decarboxylase was present in the human seminal plasma and that its activity was lower in fertile men than in infertile men. The Km and Vmax of the enzyme were, re...
Role of Hyaluronidase in Fertilization: The Antifertility Activity of Myocrisin, a Nontoxic Hyaluronidase Inhibitor
myocrisin hyaluronidase inhibitor fertilization contraception
2009/2/18
Myocrisin, a hyaluronidase inhibitor of low molecular weight, was tested for antifertility activity. In addition, the effect of myocrisin on penetration of the follicle cell layer by spermatozoa w...
Acrosin, Proacrosin, and Acrosin Inhibitor of Human Spermatozoa：Extraction, Quantitation, and Stability
acrosin proacrosin acrosin inhibitor human spermatozoa
2009/2/18
Ten different methods were evaluated to determine the treatment for obtaining maximal amounts of acrosin, proacrosin, and acrosin inhibitor (the acrosin system) from human spermatozoa by a single te...
Effect of N-acetylsphingosine (C2) and the ceramidase inhibitor (1S,2R)-D-erythro-2-（N-myristoylamino）-1-phenyl-1-propanol on the regulation of Sertoli cell function
N-acetylsphingosine (C2) (1S,2R)-D-erythro-2-（N-myristoylamino）-1-phenyl-1-propanol Sertoli cell function
2009/2/18
In the present study, a possible role of ceramide in the regulation of Sertoli cell function was investigated. Intracellular ceramide levels were increased by adding N-acetylsphingosine (C2) or by i...
Testosterone-dependent restoration of spermatogenesis in adult rats is impaired by a 5alpha-reductase inhibitor
Testosterone-dependent restoration spermatogenesis adult rats 5alpha-reductase inhibitor
2009/2/18
Germ cell development (spermiogenesis in particular) in the adult rat is known to be testosterone dependent. Recently we proposed a role for the 5alpha reduction of testosterone to dihydrotestostero...
Effects of a 5 alpha-reductase inhibitor, finasteride, on the developing prostate and testis of a marsupial
Virilization Wolifian duct tammar wallaby androgen dihydrotestosterone
2009/2/17
This study examines the role of dihydrotestosterone in virilization of the developing male tammar. The onset of prostate differentiation in this marsupial species normally occurs around 25 days po...
Anti-proliferative effect of the kinase inhibitor K252a on human prostatic carcinoma cell lines
Anti-proliferative effect kinase inhibitor K252a human prostatic carcinoma cell lines
2009/2/16
Members of the K252 family of kinase inhibitors have been demonstrated to inhibit a number of neurotrophin-mediated cellular responses, and to preferentially inhibit the activity of neurotrophin recep...
Chloride efflux during the progesterone-initiated human sperm acrosome reaction is inhibited by lavendustin A, a tyrosine kinase inhibitor
GABAA receptor Cl- channel
2009/2/16
Previous studies showed that progesterone (P) can initiate the mammalian sperm acrosome reaction (AR) in vitro and that a sperm GABAA-like receptor/Cl- channel is involved in an essential Cl- effl...