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近日，山东大学公共卫生学院孙强教授和山东省肿瘤医院王家林研究员团队在医学Top期刊Cancer上发表了题为“Long-term Effectiveness of One-time Endoscopic Screening for Esophageal Cancer: A Community-Based Study in Rural China”的研究论文，定量化揭示了食管癌内镜筛查效果的显著性和持...
From GWAS to transcriptomics in prospective cancer design - new statistical challenges
Post -GWAS Transcriptomics Nested case -control Functional changes Biomarkers
2013/4/27
Background. With the increasing interest in post-GWAS research which represents a transition from genome-wide association discovery to analysis of functional mechanisms, attention has been lately focu...
A sparse regulatory network of copy-number driven expression reveals putative breast cancer oncogenes
sparse regulatory network copy-number driven expression reveals
2010/10/19
The influence of DNA cis-regulatory elements on a gene's expression has been intensively studied. However, little is known about expressions driven by trans-acting DNA hotspots. DNA hotspots harborin...
An integrative analysis of cancer gene expression studies using Bayesian latent factor modeling
micro-environmental parameters in cancer Weibull survival models
2010/10/19
We present an applied study in cancer genomics for integrating data and inferences from laboratory experiments on cancer cell lines with observational data obtained from human breast cancer studies. T...
Bayesian Hierarchical Multiresolution Hazard Model for the Study of Time-Dependent Failure Patterns in Early Stage Breast Cancer
Multiresolution models Bayesian survival analysis hazard estimation
2009/9/22
In this paper, we extend the previously proposed MRH methods(Bouman et al.2005, 2007) into the hierarchical multiresolution hazard setting (HMRH), to accommodate the case of separate hazard rate funct...
Statistical models to study subtoxic concentrations for some standard mutagens in three colon cancer cell lines
Inverse regression problem subtoxic concentration confidence interval
2009/2/23
The aim of this work is to propose models to study the toxic effect of different concentrations of some standard mutagens in different colon cancer cell lines. We find estimates and, by means of an in...