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Loss of intercalated cells (ITCs) in the mouse amygdala of Tshz1 mutants correlates with fear, depression and social interaction phenotypes
brain development telencephalon transcription factor
2018/3/5
The intercalated cells (ITCs) of the amygdala have been shown to be critical regulatory components of amygdalar circuits, which control appropriate fear responses. Despite this, the molecular processe...
Therapeutic brain modulation with targeted large neutral amino acid supplements in the Pah-enu2 phenylketonuria mouse model
phenylketonuria inborn error of metabolism large neutral amino acids mouse model neurotransmitters brain biochemistry treatment
2018/12/18
Background: Phenylketonuria treatment consists mainly of a Phe-restricted diet, which leads to suboptimal neurocognitive and psychosocial outcomes. Supplementation of large neutral amino acids (LNAAs)...
Tudor Domain Containing Protein TDRD12 Expresses at the Acrosome of Spermatids in Mouse Testis
Tdrd12 Tudor Spermatogenesis Acrosome Spermatid Testis
2016/7/27
Tdrd12 is one of tudor domain containing (Tdrd) family members. However, the expression pattern of Tdrd12 has not been well studied. To compare the expression levels of Tdrd12 in various tissues, real...
A New View of Brain Development:Scientists Uncover Striking Differences Between the Adult and Newborn Mouse Brain
Brain Development Scientists Striking Differences Adult Newborn Mouse Brain
2016/7/4
Columbia scientists have found that spikes in the activity of neurons in young mice do not spur corresponding boosts in blood flow — a discovery that stands in stark contrast to the adult mouse brain....
Acute stress-induced changes in hormone and lipid levels in mouse plasma
acute stress corticosterone hormones
2016/2/23
We evaluated the conventional acute stress model in mice and investigated the stress-induced changes in concentrations of plasma lipids and hormones such as corticosterone (CORT), insulin, glucagon, t...
Disruptions to embryonic reprogramming alter adult mouse behavior
embryonic reprogramming adult mouse
2016/2/22
Right after fertilization, embryos at the earliest stages of development tell their genes: "Forget what it was like in the sperm or egg where you came from."
When the process of epigenetic reprogramm...
Vitrification by Cryotop and the Maturation, Fertilization, and Developmental Rates of Mouse Oocytes
Vitrification Fertilization Maturation Cryotop Developmental Rate Oocyte
2015/11/9
Background: Oocyte cryopreservation is an important part of modern fertility treatment. The effect of vitrification on the fertilization and developmental rates of embryo is still a matter of debate.
Alpha-Amanitin Poisoning, Nephrotoxicity and Oxidative Stress: An Experimental Mouse Model
Alpha-Amanitin Oxidative Stress Mycotoxins
2015/11/9
Background: Alpha-amanitin (α-AMA) plays a major role in Amanita phalloides poisoning, showing toxic effects on multi-organs, particularly on the liver and kidneys. Studies have shown a relationship b...
Rapamycin Influences the Efficiency of In vitro Fertilization and Development in the Mouse: A Role for Autophagic Activation
Vitrification Mouse Oocyte Rapamycin Development
2016/11/10
The mammalian target of rapamycin (mTOR) regulates cellular processes such as cell growth, metabolism, transcription, translation, and autophagy. Rapamycin is a selective inhibitor of mTOR, and induce...
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
Fragile X mGluR MPEP audiogenic seizures open field fmr1
2015/8/3
Fragile X Syndrome is the most common form of inherited mental retardation worldwide. A Fragile X mouse model, fmr1, with a disruption in the X-linked Fmr1 gene, has three substantial deficits observe...
Histomorphometric changes in repaired mouse sciatic nerves are unaffected by the application of a scar-reducing agent
histomorphometry nerve regeneration nerve repair scarring sciatic nerve
2015/7/22
Microsurgical repair of transected peripheral nerves is compromised by the formation of scar tissue and the development of a neuroma, thereby limiting the success of regeneration. The aim of this stud...
FUNCTIONAL GENOMICS STUDY TO UNDERSTAND THE ROLE OF SEROTONIN IN MOUSE EMBRYONIC STEM CELLS
Serotonin mouse embryonic stem cells
2015/5/26
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that is synthesized from the amino acid L-tryptophan and is reported to localize in mitochondria of embryonic stem cells. Even bef...
Development and Application of a Mass Spectrometry-Based Quantitative Assay for Apolipoprotein M in Human and Mouse Serum
Mass Spectrometry Cholesterol Apolipoprotein M MS-Based Assay
2015/5/26
Apolipoprotein M (apoM) is necessary for the formation of lipid-poor preβ-HDL particles, the initial precursor of HDL and acceptors of cholesterol efflux from peripheral cells. An assay to quantify ap...
Antinociceptive mechanisms of Bunium persicum essential oil in the mouse writhing test: role of opioidergic and histaminergic systems
Bunium persicum antinociception
2015/5/25
The aim of the current study was to determine antinociceptive mechanisms of B. persicum essential oil
using an acetic acid-induced writhing test as a model of visceral pain and to determine the poss...
TRANSGENIC USE OF SMAD7 TO SUPPRESS TGFβ SIGNALING DURING MOUSE DEVELOPMENT
heart development doxycycline inducible
2015/5/25
Neural crest cells (NCC) are a multipotent population of cells that form at the dorsal region of neural tube, migrate and contribute to a vast array of embryonic structures, including the majority of ...