搜索结果: 1-15 共查到“c-Met”相关记录76条 . 查询时间(0.149 秒)
间质表皮转化因子 (c-Mesenchymal-epithelial transition factor, c-Met)是受体酪氨酸激酶的一种，在肝癌、肺癌、结肠癌、乳腺癌、胰腺癌、卵巢癌、前列腺癌和胃癌以及其他癌症等多种恶性肿瘤中观察到c-Met失调。c-Met的过表达或突变导致信号转导异常活跃，促进肿瘤生长、血管生成和癌症转移。c-Met/HGF轴在肿瘤免疫中发挥着重要作用，因此是一个成熟的分...
日前，由胸科医院肿瘤科陆舜教授团队领衔的“赛沃替尼治疗MET外显子14跳跃突变的肺肉瘤样癌及其他非小细胞肺癌”的临床研究结果取得重要成果，获国际顶尖学术期刊《柳叶刀·呼吸医学》在线发表。基于此项研究成果，由我国自主研发的创新1.1类新药赛沃替尼于6月22日获国家药品监督管理局批准上市，用于治疗MET外显子14跳跃突变的非小细胞肺癌。作为在全球范围内的首次获批，赛沃替尼不仅填补了国内此类靶向药的空白...
研究 c-Met 基因下调后对结直肠癌侵袭和转移的影响机制。方法 在 SW480 细胞中敲低 c-Met 基因，通过基因芯片筛选差异基因，对差异基因进行功能聚类分析，通过 IPA 分析细胞信号通路和相关的差异基因相互作用网络以及相关基因与上游调控分子间的作用关系。选取被抑制的信号通路中的相关基因进行 qPCR 验证。
MET扩增与非小细胞肺癌EGFR-TKI耐药的相关性
MET扩增 表皮生长因子受体酪氨酸激酶抑制剂 耐药 癌,非小细胞肺
2020/6/24
MET是一个常见于肺癌患者的原癌基因。MET扩增与非小细胞肺癌肺癌患者的不良预后有关,其参与了肺癌细胞的增殖、存活、凋亡、侵袭、迁移和血管生成。研究证实MET扩增是一代及三代表皮生长因子受体酪氨酸激酶抑制剂 (EGFR-TKI)的重要耐药机制,患者使用克唑替尼达到克服 MET扩增所致EGFR-TKI耐药的效果。
肺癌脉管内癌栓中EGFR、ERCC1和c-Met的相关性分析
肺肿瘤 病理学 受体 表皮生长因子 代谢 原癌基因蛋白质c-met 基因表达 肿瘤侵润 免疫组织化学
2020/8/14
分析肺癌患者脉管内癌栓（intravascular cancer embolus，ICE）与表皮生长因子受体（epidermal growth factor receptor，EGFR）、核苷酸切除修复交叉互补基因-1（excision repair-cross complementing-1，ERCC1）和c-Met表达的关系以及对疾病预后的影响。方法 采用免疫组织化学法检测EGFR、ERCC1...
URBAN MICROCLIMATE IMPROVEMENT USING ENVI-MET CLIMATE MODEL
Urban Microclimate simulation vegetation scenarios
2018/11/9
The aim of this paper is the modelling of urban microclimate, based on the limits imposed by the complexity of the three-dimensional space of cities. To this purpose, different Bioclimatic Scenarios w...
When corals met algae:Symbiotic relationship crucial to reef survival dates to the Triassic
corals algae Symbiotic relationship reef survival dates the Triassic
2016/11/29
The mutually beneficial relationship between algae and modern corals — which provides algae with shelter, gives coral reefs their colors and supplies both organisms with nutrients — began more than 21...
中国科学院上海药物研究所c-Met抑制剂疗效监控标志物研究取得新进展
中国科学院上海药物研究所 抑制剂 药
2015/11/5
近年来，基于病人遗传特征的个体化治疗已经成为肿瘤靶向治疗的核心，也是“精准医疗”的重要组成部分。其中，蛋白激酶抑制剂已经在肿瘤癌基因分子分型的指导下，在肿瘤的临床治疗中取得了巨大成功。然而，随之而来的是广泛频发的激酶抑制剂耐药问题，造成临床响应率低、肿瘤易复发，已经严重制约了蛋白激酶抑制剂的临床疗效。据此，开发疗效监控标志物，及时评判药物疗效以甄别获益人群，并实时监控耐药发生已经成为当下的研究重点...
Development of the Global Sea Ice 6.0 CICE configuration for the Met Office Global Coupled model
Global Sea Ice 6.0 CICE Met Office Global Coupled model
2015/8/6
The new sea ice configuration GSI6.0, used in the Met Office global coupled configuration GC2.0, is described and the sea ice extent, thickness and volume are compared with the previous configuration ...
Three-dimensional visualization of ensemble weather forecasts–Part 1:The visualization tool Met.3D (version 1.0)
Three-dimensional visualization ensemble weather visualization tool Met.3D
2015/8/6
We present "Met.3D", a new open-source tool for the interactive three-dimensional (3-D) visualization of numerical ensemble weather predictions. The tool has been developed to support weather forecast...
Management and the Financial Crisis (We have met the enemy and he is us...)
Accounting Audits Financial Crisis International Finance Corporate Governance Governing Rules
2015/4/22
The financial crisis of 2008-9 has revealed that our broad model of corporate governance is broken, independent of the shortcomings in the regulatory system. Managers and boards of directors in scores...
Energy and Macronutrient Intake in the Midwest Exercise Trial 2 (MET-2)
ENERGY INTAKE MACRONUTRIENT INTAKE OBESITY HEALTH EATING INDEX EXERCISE
2017/4/20
Purpose: This study aimed to examine the effect of exercise training over 10 months at two levels of energy expenditure on energy and macronutrient intake in a sample of previously sedentary, overweig...
Recent development of the Met Office operational ocean forecasting system: an overview and assessment of the new Global FOAM forecasts
he Met Office operational ocean forecasting system the new Global FOAM forecasts
2014/12/19
The Forecast Ocean Assimilation Model (FOAM) is an operational ocean analysis and forecast system run daily at the Met Office. FOAM provides modelling capability in both deep ocean and coastal shelf s...
The Met Office Unified Model Global Atmosphere 4.0 and JULES Global Land 4.0 configurations
Met Offi ce Unifi ed Model Global Atmosphere JULES Global Land
2014/12/18
We describe Global Atmosphere 4.0 (GA4.0) and
Global Land 4.0 (GL4.0): configurations of the Met Office
Unified Model and JULES (Joint UK Land Environment
Simulator) community lan...
GO5.0: the joint NERC–Met Office NEMO global ocean model for use in coupled and forced applications
Met Offi ce NEMO forced applications
2014/12/18
We describe a new Global Ocean standard configuration (GO5.0) at eddy-permitting resolution, developed
jointly between the National Oceanography Centre and the
Met Office as part of the ...