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肢端型黑色素瘤（acral melanoma, AM）是一种起源于手掌、足底和甲下等部位的恶性皮肤肿瘤，也是亚洲人群中最主要的黑色素瘤亚型。原位AM（AM in situ, AMis）突破基底膜进入真皮发展为侵袭性AM（invasive AM, iAM）是造成患者预后变差的重要里程碑事件。然而，目前关于AMis的研究仍然十分有限，AMis向iAM的演化过程尚不清楚，免疫微环境在这一过程中发挥的作用...
肝癌是中国高发恶性肿瘤。由于其广泛的肿瘤异质性，最新的靶向联合免疫治疗的方案仅对20~30%的患者有效，并且缺乏指导精准用药的药敏分子分型。因此亟需研究可以指导肝癌精准用药的分子分型和揭示新的耐药靶点。
近日，首都医科大学基础医学院李长龙副教授团队在《Gastric Cancer》上发表题为“Sustained exposure toHelicobacter pylori induces immune tolerance bydesensitizing TLR6” 的研究论文。该研究揭示了幽门螺杆菌（Hp）持续感染过程中，通过调控宿主胃上皮细胞TLR6/JNK信号通路抑制IL-8分泌，减少中性粒细...
2023年12月2日，国家纳米科学中心聂广军研究员、李素萍研究员团队应邀对肿瘤进展过程中血小板的动态作用及其治疗意义进行了深入探讨和系统总结，相关综述以The dynamic role of platelets in cancer progression and their therapeutic implications为题在线发表于Nature Reviews Cancer期刊（Nature ...
近日，皖南医学院第一附属医院神经系统疾病医学转化中心研究团队与新加坡国立大学杨潞龄医学院（NUS Yong Loo Lin School of Medicine）Chen Xiaoyuan Shawn（陈小元）教授团队、东南大学中大医院生命健康高等研究院夏洪平教授团队紧密合作，在《Nature Cancer》发表了题为“An in vitro-transcribed circular RNA ta...
MACdb数据库系统建立了癌症-代谢物关联关系的收集标准，通过使用一系列本体体系（Ontology）对癌症类型、特征、代谢物标准化，构建了高一致性的综合知识集合。当前版本的知识库共收录了462篇文献，提取了40,710个癌症-代谢物关联关系对，共涉及到269个癌症特征，涵盖17类高发病率或高死亡率癌症类型，是当前涵盖癌症类型最全的癌症-代谢物关联知识库。MACdb构建了便捷高效的检索和过滤系统，支...
RNA nanoparticle therapy stops the spread of incurable bone marrow cancer（图）
RNA 纳米颗粒疗法 骨髓癌 肿瘤治疗
2023/6/27
Multiple myeloma is an incurable bone marrow cancer that kills over 100,000 people every year. Known for its quick and deadly spread, this disease is one of the most challenging to address. As these c...
Data suggests stopping immunotherapy after two years is reasonable in patients with advanced lung cancer（图）
晚期肺癌 免疫治疗 停止治疗
2023/6/27
Over the past decade, the approval of immune checkpoint inhibitors has revolutionized treatment for patients with advanced lung cancer, helping many live longer lives and improving overall survival fo...
In the five years since the FDA’s initial approval of chimeric antigen receptor (CAR) T cell therapy, Penn Medicine has gleaned 20 additional approvals related to drugs and techniques to treat or dete...
Every three to five days, all of the cells lining the human intestine are replaced. That constant replenishment of cells helps the intestinal lining withstand the damage caused by food passing through...
In what may turn out to be a long-missing piece in the puzzle of breast cancer, Harvard Medical School researchers have identified the molecular sparkplug that ignites cases of the disease currently u...
Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development. However, for the vast majority of those mutations, researchers are unsure of how they contribute to...
中科院上海分院营养与健康所胡国宏研究员受邀在Cancer Cell上发表研究专评（图）
胡国宏 肿瘤细胞 循环
2023/6/16
2023年5月8日，中国科学院上海营养与健康研究所胡国宏研究员受邀在国际知名学术期刊Cancer Cell上发表题为“A genetic portrait of metastatic seeds in lung adenocarcinoma”的专评文章，对该刊同期发表的一项题为“Genomic mapping of metastatic organotropism in lung adenocar...
中国科学院上海营养与健康所胡国宏研究员受邀在Cancer Cell上发表研究专评
胡国宏 基因 器官
2023/11/30
2023年5月8日，中国科学院上海营养与健康研究所胡国宏研究员受邀在国际知名学术期刊Cancer Cell上发表题为“A genetic portrait of metastatic seeds in lung adenocarcinoma”的专评文章，对该刊同期发表的一项题为“Genomic mapping of metastatic organotropism in lung adenocar...
近日，中南大学湘雅医院癌变机理与靶向治疗研究中心肖志强教授团队在肿瘤免疫治疗学专业期刊“肿瘤免疫治疗杂志”《J Immunother Cancer》(IF: 12.469)上发表了题为“ANXA1-derived peptide for targeting PD-L1 degradation inhibits tumor immune evasion in multiple cancers”的原创...