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PAK1's regulation of eosinophil migration and implications for asthmatic inflammation
airway inflammation p-21 activated kinase 1 (PAK1) chemotaxis
2015/5/21
More than 300 million people world-wide suffer from breathlessness, wheezing, chest tightness, and coughing characteristic of chronic bronchial asthma, the global incidence of which is on the rise. Al...
Corneal and Conjunctival Fibroblasts Are Major Sources of Eosinophil-Recruiting Chemokines
chemokine conjunctiva epithelial cells fibroblast gene expression
2010/11/16
Corneal and conjunctival fibroblasts exhibited marked increases in the expression of chemokines upon stimulation with TNF-α and IL-4, suggesting that fibroblasts may be one of the primary sources of c...
Urinary Eosinophil-derived Neurotoxin Concentrations in Patients with Atopic Dermatitis: A Useful Clinical Marker for Disease Activity
atopic dermatitis eosinophil eosinophil-derived neurotoxin visual analogue scale
2010/11/18
Background: It has been reported that measurements of eosinophil-derived neurotoxin (EDN) may be useful for identifying eosinophil activities in allergic diseases including atopic dermatitis.
Methods...
Serum Concentrations of Eosinophil Cationic Protein and Eosinophils of Patients with Kimura's Disease
EG-2 eosinophil cationic protein eosinophils Kimura's disease
2010/11/18
Background: To clarify the role of eosinophils in the pathogenesis of Kimura's disease and the values of measuring serum levels of eosinophil cationic protein (ECP) for monitoring disease activity mig...
Agreement Rate of Skin Prick Test with Tissue Eosinophil Count in Patients with Nasal Polyps
Eosinophil Skin Prick Test
2010/4/9
The pathogenetic mechanism of nasal polyps remains unknown, although allergy has been cited as an important factor in the etiology of nasal polyposis. Currently there is no definite histological
crit...
Role of Protein Kinase C in Eosinophil Function
eosinophils PKC inhibitors PKC isoform protein kinase C (PKC) signal transduction
2010/11/19
Protein kinase C (PKC) isoforms are being elucidated as an increasingly diverse family of enzymes involved in the downstream signal transduction and cell function in various types of cells. To date, 1...
Non-specific activation of human eosinophil functional responses by vasoactive intestinal peptide
allergic inflammation eosinophil functional response signal transduction vasoactive intestinal peptide
2010/11/25
Eosinophils and neuropeptides are thought to play effector roles in allergic diseases, such as rhinitis; however, little is known about the biological effects of neuromediators, especially vasoactive ...
Eosinophil hypersegmentation is a possible marker to monitor the disease activity of atopic dermatitis
atopic dermatitis eosinophils nuclear lobes of eosinophils
2010/11/25
Background: In the present study, we tried to clarify whether nuclear hypersegmentation of peripheral blood eosinophils is correlated with peripheral eosinophil counts and/or the activity of atopic de...
Role of adhesion molecules in eosinophil activation: A comparative study on the effect of adhesion molecules on eosinophil survival
adhesion molecule β integrin eosinophil fibronectin survival
2010/11/22
Background: Adhesion molecules participate in an important part of inflammatory process in relation to the accumulation of inflammatory cells, such as eosinophils. The expression of adhesion molecules...
Concentrations of eosinophil-derived neurotoxin in the blood and urine of patients with allergic diseases
allergic rhinitis atopic dermatitis bronchial asthma eosinophil-derived neurotoxin eosinophil
2010/11/24
The median concentrations of EDN in blood and urine and the number of eosinophils in peripheral blood from patients with active symptoms were all significantly higher compared with values obtained whe...
Platelet-activating Factor or Complement 5a Causes Distinct Activation Profiles in Human Eosinophil and Neutrophil Functions
adhesion complement 5a eosinophils neutrophils platelet-activating factor superoxide anion β2 integrin
2010/11/19
Eosinophils and neutrophils showed different activation profiles with stimulation of PAF or C5a on HSA-coated surfaces. In eosinophils the intensity of cellular adhesion and O2- release paralleled the...
Tulobuterol, a β2-agonist, Attenuates Eosinophil Adhesion to Endothelial Cells
cell adhesion endothelial cells eosinophils tulobuterol β2-agonist
2010/11/19
Background: Transdermal patches containing tulobuterol, slow-releasing β2-agonist patches, are now widely used in the treatment of asthma in Japan. Unlike inhalational β2-agonists, tulobuterol patches...
Serum eosinophil cationic protein levels can be useful for predicting acute exacerbation of asthma
asthma attack eosinophil cationic protein predictive marker
2010/11/29
We report on a case in which five consecutive exacerbations of asthma were monitored by following serum eosinophil cationic protein (ECP) levels. The serum ECP level correlated well with each exacerba...
Latex allergy in a dental nurse: Late nasal response is associated with eosinophil recruitment and T helper 2 cell type cytokine mRNA expression
eosinophils late nasal responses latex allergy T cells Th2 type cytokine
2010/11/29
The occupational uses of latex gloves may be associated with allergic rhinitis. Hypersensitivity to latex has been shown to be IgE-mediated. However, late nasal responses to latex have not been report...
Short-term stimulation with interleukin (IL)-4 enhances purified protein derivative-induced production of an eosinophil chemotactic lymphokine, but suppresses IL-5 production
eosinophil chemotactic lymphokine granulocyte—macrophage colony stimulating factor interferon-γ interleukin-4 interleukin-5 RANTES
2010/11/29
The effect of interleukin (IL)-4 on eosinophil chemotactic lymphokine (ECL) production from peripheral blood mononuclear cells (PBMC) stimulated with purified protein derivative (PPD) was examined. Th...