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造血干细胞(HSCs)在人类整个生命周期中再生血细胞,为了维持其健康状态,HSCs特别依赖于蛋白质稳态。然而,HSCs如何清除错误折叠的蛋白质尚不清楚。近期,加州大学圣地亚哥分校与拉霍亚免疫学研究所的一项联合研究发现,HSCs优先将错误折叠的蛋白质运输到聚集体中,并依赖聚集体自噬在体内维持蛋白质稳态。研究成果发表在《Cell Stem Cell》期刊,标题为“Hematopoietic stem ...
Every day, billions of red blood cells pass through the spleen, an organ that is responsible for filtering out old or damaged blood cells. This task is made more difficult when the blood cells are mis...
急性髓性细胞白血病(AML)是一种侵袭性血癌,预后较差。Fms样酪氨酸激酶受体3(FLT3)是AML中异常激活的主要致癌受体酪氨酸激酶之一。尽管目前针对FLT3相关抑制剂的研究日趋深入,越来越多的新型抑制剂进入了临床试验,但是仍然有特异性不高、药物相关不良反应以及药物耐药等局限性。
In the summer of 2010, Bill Ludwig and Doug Olson were battling an insidious blood cancer called chronic lymphocytic leukemia (CLL). They’d both received numerous treatments, and as remaining options ...
10 May 2007,Scientists from the University of Sheffield are developing an artificial `plastic blood´, which could act as a substitute for real blood in emergency situations. The `plastic blood&a...
1 May 2007,An Oxford University study has suggested that the number of people over 75 having certain types of stroke has increased in the last 25 years due to the use of ‘blood-thinning’ drugs, includ...
13 April 2007,Human bone marrow has been used to create early-stage sperm cells for the first time, a scientific step forward that will help researchers understand more about how sperm cells are creat...
April 27, 2007,The U.S. Food and Drug Administration (FDA) today approved Humate-P (Antihemophilic Factor/von Willebrand Factor Complex) for the prevention of excessive bleeding during and after surge...
April 06, 2007,EAST LANSING, Mich. — Jaime Escalante, a mathematics teacher whose life inspired the movie “Stand and Deliver,” and Julie Gerberding, who played a major role in leading the Centers for ...
March 16, 2007,The U.S. Food and Drug Administration (FDA) today approved Soliris (eculizumab), the first product for the treatment of paroxysmal nocturnal hemoglobinuria (PNH), a rare type of blood d...
March 20, 2007,Also known as a DVT, it is a blood-clotting disorder that kills as many as 300,000 Americans every year – more than breast cancer and AIDS combined.
March 12, 2007,Millions of times during their four-month lifespan, human red blood cells must squeeze through tiny capillaries to deliver their payload of oxygen and pick up waste carbon dioxide-funct...
March 2, 2007,The U.S. Food and Drug Administration (FDA) today announced the approval of a license supplement for the first fully automated West Nile Virus (WNV) nucleic acid test for donor screening...
January 22, 2007,The two dominant proteins that determine how much blood flows through the body’s arteries have been implicated in Alzheimer’s disease, in a new study in the Jan. 16 issue of the Proce...
January 16, 2007,The Food and Drug Administration (FDA) today issued a draft guidance recommending a streamlined path to licensure for establishments that manufacture cord blood for certain medical co...

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