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Coenzyme Q10 prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth
developmental programming liver disease coenzyme Q low birth weight accelerated postnatal growth
2018/11/28
Background: It is well established that low birth weight and accelerated postnatal growth increase the risk of liver dysfunction in later life. However, molecular mechanisms underlying such developmen...
Signaling mechanisms that suppress the anabolic response of osteoblasts and osteocytes to fluid shear stress
Mechanotransduction Osteoblast Osteocyte
2015/5/22
Bone is a dynamic organ that responds to its external environment. Cell signaling cascades are initiated within bone cells when changes in mechanical loading occur. To describe these molecular signali...
Temperature Effects on Growth and Stress Physiology of Brook Trout: Implications for Climate Change Impacts on an Iconic Cold-Water Fish
growth stress heat shock protein cortisol
2015/1/4
Despite the threat of climate change, the physiological mechanisms by which temperature drives the distribution of species are unclear. Here we used chronic temperature exposures to determine that the...
Stress can speed ageing, study shows
stress ageing
2009/8/26
A lifetime of stress can take its toll on the body and accelerate the ageing process, a study of wild animals suggests.Scientists at the University found that wild sheep forced to contend with difficu...
Mitochondrial ATP-Sensitive Potassium Channel Activation Protects Cerebellar Granule Neurons From Apoptosis Induced by Oxidative Stress
Mitochondrial ATP-Sensitive Oxidative Stress
2014/3/31
ptosis contributes to ischemic injury in the brain,
4
and
brain mitochondria contain 7 times more mitoK
ATP
channels
than heart mitochondria.
5
Several reports have shown that
mitoKATP
chann...
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated Stress Inflammation
2014/3/31
Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of eukaryotic cell regulation. All eukaryotic cells possess multiple MAPK pathways, each o...