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2017疾病模式识别信号 Keystone Symposia（2017 Keystone Symposia on Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease）
PRR Signaling Inflammatory Disease
2017/1/13
The meeting will begin on Sunday, March 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 23 with a closing plenary sessio...
Microbial modulation of innate defense: goblet cells and the intestinal mucus layer
goblet cells mucins mucus
2016/6/14
The gastrointestinal epithelium is covered by a
protective mucus gel composed predominantly of mucin glycoproteins
that are synthesized and secreted by goblet cells.
Changes in goblet cell function...
Innate Immune Mechanisms: Nonself Recognition
固有免疫机制：非己的识别 Innate Immune Mechanisms: Nonself Recognition
2014/6/24
The innate immune system contains a range of cell-bound and soluble proteins which eliminate pathogens by recognizing unique molecular patterns expressed by microorganisms, but not by host cells. Alte...
Effects of Aerobic Exercise on Lipid-Effector Molecules of the Innate Immune Response
MUCOSAL IMMUNITY ANTIMICROBIAL PEPTIDES EPITHELIAL CELLS FREE FATTY ACIDS CHOLESTERYL ESTERS AEROBIC FITNESS
2017/5/18
Consistent, moderate-to-vigorous-intensity exercise has been associated with a lower risk of upper respiratory tract infection (URI). However, the molecular basis for this apparent protection has not ...
The Inflammasome, an Innate Immunity Guardian, Participates in Skin Urticarial Reactions and Contact Hypersensitivity
contact hypersensitivity IL-1β inflammasome NLRP3 urticaria
2010/11/12
Urticarial rash, one of the clinical manifestations characteristic of cryopyrin-associated periodic syndrome (CAPS), is caused by a mutation in the gene encoding for NLRP3 (nucleotide-binding oligomer...
Acute stress augments innate immunity in the liver and increases hyaluronan levels in the tissues and blood of mice
increases hyaluronan levels blood of mice
2009/12/16
The effect of acute stress on the immune system was examined in mice. Restraint stress decreased the number of lymphocytes in the liver, whereas the number of lymphocytes remained unchanged in the spl...
The Dynamics of Dendritic Cell—Mediated Innate Immune Regulation
cDCs crosstalk C-type lectin IFN-α pDC
2010/11/18
After taking up pathogen-derived antigens, dendritic cells (DCs) leave peripheral organs and migrate into sentinel lymph nodes via afferent lymphatic vessels. During this process, they undergo maturat...
Basophils: A Potential Liaison between Innate and Adaptive Immunity
adaptive immunity basophils IL-4 innate immunity parasites
2010/11/18
Activation of innate immunity is closely associated to development of protective adaptive immune response. Significant advances have been made to reveal such links between innate immunity and Th1 type...