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Metabolic Adaptations in the Liver of Born Long-Distance Running Mice
PPAR DELTA SIRTUIN 1 LIVER METABOLISM GLUCONEOGENESIS, LIPOGENESIS
2017/7/17
Purpose: Long-distance runners have increased needs of energy supply. To unravel genetically based mechanisms required for efficient energy supply, we have analyzed hepatic metabolism of mice characte...
Synergistic effects of Isatis tinctoria L. and tacrolimus in the prevention of acute heart rejection in mice
satis tinctoria L mice
2013/6/26
Although immunosuppressive treatments are available for acute cardiac rejection no viable treatment exists for long-term cardiac graft failure. Moreover, the extended use of calcineurin inhibitor immu...
Monoclonal antibody treatment to prolong the secondary cardiac allograft survival in alloantigen-primed mice
Monoclonal antibody mice
2013/6/26
We have previously shown that costimulation blockade using a combination of monoclonal antibodies (mAbs) - CTLA4Ig, antibodies to CD154, LFA-1, and OX40L - can induce tolerance of cardiac allografts i...
Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4(+) memory T cells in mice
Rapamycin tacrolimus rejection
2013/6/26
Donor-reactive memory T (Tm) cells undermine transplanted organs more readily than naive T cells. Rapamycin (RAPA) and tacrolimus (FK-506) are current mainstay immunosuppressants used for preventing a...
Suppressing memory T cell activation induces islet allograft tolerance in alloantigen-primed mice." Transpl Int
ctivation induces islet Suppressing memory
2013/6/26
Summary Memory T cells are known to play a key role in prevention of allograft tolerance in alloantigen-primed mice. Here, we used an adoptively transferred memory T cell model and an alloantigen-prim...
Isatis tinctoria L. combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice
Isatis molecules prolongs
2013/6/26
Memory T cells present a unique challenge in transplantation. Although memory T cells express robust immune responses to invading pathogens, they may be resistant to the effects of immunosuppressive t...