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Early Steps of Supported Bilayer Formation Probed by Single Vesicle Fluorescence Assays
Adsorption Diffusion Lipid Bilayers Lipid Bilayers Liposomes Membrane Fluidity Membrane Fusion Membranes,Artificial Microscopy,Fluorescence,Multiphoton Motion Phosphatidylcholines Phosphatidylserines Xanthenes
2016/5/24
We have developed a single vesicle assay to study the mechanisms of supported bilayer formation. Fluorescently labeled, unilamellar vesicles (30-100 nm diameter) were first adsorbed to a quartz surfac...
Micropattern Formation in Supported Lipid Membranes
Lipid Bilayers Phospholipids Microchemistry Diffusion Membrane Fluidity Electrochemistry
2016/5/24
Phospholipid vesicles exhibit a natural tendency to fuse and assemble into a continuous single bilayer membrane on silica and several other substrate materials. The resulting supported membrane mainta...
Arrays of Independently-Addressable Supported Fluid Bilayer Membranes
Arrays Independently Addressable Fluid Bilayer Membranes
2016/5/23
A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions...
Patterning and Composition Arrays of Supported Lipid Bilayers by Microcontact Printing
biological molecules-nucleic acids self-assembly scanning tunneling microscopy gold
2016/5/23
Fluid-supported lipid bilayers self-assemble on glass and SiO2 surfaces. We have found that it is also possible to assemble fluid bilayers on plasma-oxidized polydimethyl siloxane (PDMS) surfaces. Fur...
Polymer-supported Lipid Bilayers on Benzophenone-modified Substrates
Polymer Lipid Bilayers Benzophenone modified Substrates
2016/5/23
Solid-supported lipid membranes are important for their roles in fundamental biophysical research as well as in applications such as biosensors. In our study, lipopolymers containing alkyl side chains...
Molecular Transport and Organization in Supported Lipid Membranes
Supported lipid membranes Molecular transport Membrane patterning PDMS stamp
2016/5/23
The mechanism by which vesicles spontaneously form supported lipid bilayer membranes on glass surfaces is becoming better understood and this knowledge is the basis of a technology of patterning membr...
Formation of Supported Lipid Bilayer Composition Arrays by Controlled Mixing and Surface Capture
tetrafluorophosphite mean amplitudes of vibration bond properties
2016/5/23
Virtually all structures in living cells are defined by lipid bilayers. Many molecular components can diffuse along these 2-dimensional structures, sampling all or part of the membrane, and this diffu...
Printing via Photolithography on Micropartitioned Fluid Lipid Membranes
Lipid membranes Liquid surfaces Micropatterning
2016/5/23
In a fluid medium there is continuous diffusive mixing among components. In order to retain spatial information such as a concentration gradient or an image in the absence of external forces, the flui...
Patterning Barriers to Lateral Diffusion in Supported Lipid Bilayer Membranes by Blotting and Stamping
Patterning Barriers Lateral Diffusion Lipid Bilayer Membranes Blotting Stamping
2016/5/23
Two new methods are introduced for patterning fluid lipid bilayer membranes on solid supports. These methods are based on the observation that supported membranes undergo self-limiting lateral expansi...
Electric Field Effects in Multicomponent Fluid Lipid Membranes
melatonin impurities bulk drug substance analytical methods impurity profile residual solvent stability purity
2016/5/23
A thermodynamic model of multicomponent fluid membranes under the influence of lateral forces is described. Membrane components are characterized by their effective molecular areas, molecular charges,...
Brownian Ratchets: Molecular Separations in Lipid Bilayers Supported on Patterned Arrays
4-Chloro-7-nitrobenzofurazan Chemistry, Physical Diffusion Electrophoresis Fluorescence Fluorescent Dyes Lipid Bilayers Membrane Fluidity Membrane Proteins Membrane Proteins Phosphatidylethanolamines Phosphatidylethanolamines Phosphatidylserines Phosphatidylserines Phospholipids Phospholipids Physicochemical Phenomena Temperature Xanthenes
2016/5/23
Brownian ratchets use a time-varying asymmetric potential that can be applied to separate diffusing particles or molecules. A new type of Brownian ratchet, a geometrical Brownian ratchet, has been rea...
Writing and Erasing Barriers to Lateral Mobility Into Fluid Phospholipid Bilayers
nematics dielectric anisotropy density viscosity
2016/5/23
We describe a method for making and erasing barriers to the lateral diffusion of membrane components in fluid lipid bilayers supported on glass substrates. When a bilayer is mechanically partitioned b...
Formation and Spreading of Lipid Bilayers On Planar Glass Supports
Formation Spreading Lipid Bilayers Planar Glass Supports
2016/5/23
The fusion and spreading of phospholipid bilayers on glass surfaces was investigated as a function of pH and ionic strength. Membrane fusion to the support was favorable at high ionic strength and low...
Substrate-Membrane Interactions:Mechanisms for Imposing Patterns on a Fluid Lipid Bilayer Membrane
X-ray resonant exchange scattering X-ray absorption fine structure surface contamination PuSb
2016/5/23
A variety of new techniques are emerging that require the use of a patterned substrate to impose micropartitions on a supported fluid bilayer membrane. The barrier-forming characteristics of aluminum ...
Electric Field-Induced Critical Demixing in Lipid Bilayer Membranes
Cardiolipins Electric Stimulation Electricity Fluorescent Dyes Lipid Bilayers Membranes, Artificial Microscopy, Fluorescence Models, Chemical Models, Molecular hosphatidylcholines Phosphatidylethanolamines Thermodynamics
2016/5/23
Electric fields can induce lateral reorganization of lipids in fluid bilayer membranes. The resulting concentration profiles readily are observed in planar-supported bilayers by epifluorescence micros...