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Gene Polymorphisms and Chemotherapy in Non-small Cell Lung Cancer
Lung neoplasms Genetic polymorphism Drug therapy
2013/12/10
The phamacogenetics is being used to predict whether the selected chemotherapy will be really effective and tolerable to the patient. Irinotecan, oxidized by CYP3A4 to produce inactive compounds, is u...
WEEKLY ASSESSMENT OF QUALITY OF LIFE IN PATIENTS WITH ADVANCED NON-SMALL-CELL LUNG CANCER DURING CHEMOTHERAPY IN A RANDOMIZED PHASE III TRIAL
Adverse event chemotherapy lung cance non-small-cell phase III trial quality of life
2009/7/15
This study investigated quality of life (QOL) in patients with advanced non-small-cell lung cancer in an early phase of chemotherapy in a randomized phase III trial. QOL assessments for four domains (...
CANCER GENE THERAPY USING CYTOKINE AND CHEMOKINE GENES
Adenovirus CC chemokine granulocyte macrophage-colony stimulating factor interleukin-2 retrovirus secondary lymphoid tissue chemokine
2009/7/15
Surgical or radiotherapy-mediated eradication of tumors gives the best opportunity for cure, if the tumor is restricted to the primary sites. Chemotherapy is employed for disseminated disease but freq...
Extensive axillary lymph node involvement in breast cancer patients selected for sentinel lymph node biopsy:incidence and implications
Breast Cancer Sentinel Extensive Under-estimation
2009/7/15
Extensive axillary lymph node involvement in breast cancer patients implies poor prognosis, and is an indication for chest wall irradiation. Patients presenting with small tumors and a negative axilla...
Use of RNA interference technology for cancer specific gene silencing
RNA interference siRNA cancer gene therapy
2009/7/15
RNA interference (RNAi) can be applied to human cancer cells by using small interfering RNAs (siRNAs) for inhibition of activated oncogenes' expression with the amelioration of several malignant pheno...
Current status of tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) targeting cancer therapy
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) TRAIL receptor 1 (TRAIL-R1), TRAIL receptor 2 (TRAIL-R2) apoptosis KM mouseTM monoclonal antibody targeting therapeutics
2009/7/15
Monoclonal antibodies have already established a secure position as a very promising strategy for anti-tumor therapeutics. High specificity and high affinity are attractive characteristics of antibodi...
Laparoscopic oophorectomy combined with breast surgery for breast cancer patients
Breast Cancer Operations Gene BRCA1 Gene BRCA2 Oophorectomy Laparoscopic Surgical Procedures Operative Prophylaxis
2009/7/15
Background Prophylactic oophorectomy is effective for risk-reduction for both breast and ovarian cancer in patients with hereditary breast/ovarian cancer syndromes. Oophorectomy in a woman with breast...
Truth-telling to Patients with Advanced Cancer:A Comparison between Cancer center, University Hospitals,General City Hospitals,and Private General Practitioners in Japan
Truth-telling advanced cancer informed consent
2009/7/15
Attitude of Japanese doctors in their practice of truth-telling to patients with non-curable terminal cancer was extensively investigated to evaluate the difference between doctors from various types ...
Outcome of HLA-oriented therapy for gastric cancer in retrospective and prospective study
gastric cancer HLA HLA-oriented therapy
2009/7/15
There are no strategies to predict a patient's response to therapy. In a previous report, we classified Japanese patients into four groups according to the incidence of HLA antigens, by using the quan...
Advanced Pancreatic Cancer Successfully Treated with Biweekly Low-Dose Gemcitabine
pancreatic cancer gemcitabine biweekly administration
2009/7/15
A 74-year-old male was admitted to our hospital in August 2006 because of an exacerbation of the symptom of diabetes mellitus. Abdominal CT showed locally advanced cancer of the head of the pancreas w...
Health Screening and Treatment for Prostate Cancer.
Clinical Experience with Smart Care for Respiratory Managementafter Esophageal Cancer Surgery
Smart Care Esophageal carcinoma Ventilator
2009/7/14
Smart Care ® (SC) is an automated weaning system which has been newly installed in the Evita XL Ventilator made by Dräger Medical (Lubeck, Germany). This study was performed to investigate th...
Outcome of Primary Endocrine Therapy in Postmenopausal Patients with Endocrine-responsive Breast Cancer
primary endocrine therapy postmenopausal breast cancer aromatase inhibitor
2009/7/14
Purpose: The purpose of this study was to investigate the efficacy and toxicity of primary endocrine therapy in postmenopausal elderly patients with endocrine-responsive breast cancer.
Patients and M...
Curative Resection after a Response to Treatment with mFOLFOX6 for Unresectable Sigmoid Colon Cancer: Report of a Case
Colon cancer neoadjuvant chemotherapy mFOLFOX6
2009/7/14
We herein report a case of curative resection, after a response to chemotherapy with mFOLFOX6, for sigmoid colon cancer which had been unresectable due to an invasion of the primary lesion into the ao...
Survival in esophageal cancer patients with hematogenous distant organ metastases
Esophageal cancer metastasis survey
2009/7/6
Objective: Esophageal cancer is a rapidly progressive cancer. In the majority of patients local invasion or distant metastasis may be present at the time of diagnosis. The present study reviewed the r...