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Testin又称睾丸素，最初是从小鼠睾丸支持细胞增菌培养基中鉴定的一种分泌性糖蛋白，可通过受体联合蛋白与细胞表面紧密结合。通过对睾丸素的研究，人们发现睾丸素 mRNA分布于全身大多数器官，尤其以睾丸和卵巢表达最高。研究表明睾丸素可能为一种抑癌基因，且当睾丸素基因表达降低或缺失时，致癌物诱导的胃癌发生率更高。
5α-还原酶有两种同工酶，可将睾酮转化成二氢睾酮(DHT)。5α-还原酶-2型同工酶的基因突变可导致此酶的活性降低从而造成男性的假两性畸形。这些患者是46XY染色体的个体,其血浆睾酮的水平为正常高值或升高而DHT水平降低，从而导致睾酮/DHT的比例升高,他们在出生时外生殖器的形态常介于男女两性之间,但中肾管分化正常。其前列腺小且发育不全，血浆中前列腺特异性抗原(PSA)的水平低或检测不到。动物实验...
目的:分析不孕不育中的男性因素。方法:收集3 777对不孕夫妇的孕产史及不孕不育病因检查结果，对男性不育患者资料进行分析，包括男性生殖专科体格检查、精液常规分析、遗传学检查等。结果:单纯男性因素不育患者1 406例，占总数的37.23％。其中无精子症在男性不育患者中占57.99％，少弱精子症及严重少弱精子症占37.34％。在无精子症及严重少弱精子症患者中，染色体异常表现有数目异常和涉及大多数染...
合并前列腺炎的良性前列腺增生组织中Ki-67，Bcl-2，Bax和caspase-3表达及意义。
目的：探讨前列腺素Ｅ１（ＰＧＥ１）阴茎海绵体注射后实时阴茎硬度检查仪（Ｒｉｇｉｓｃａｎ）结合多
普勒超声技术诊断勃起功能障碍（ＥＤ）的价值。方法：１９９８年１月至２００７年１２月间的１３９２例ＥＤ患
者，使用ＰＧＥ１ 阴茎海绵体注射，Ｒｉｇｉｓｃａｎ连续记录１ｈ，观察阴茎勃起情况。使用阴茎彩色超声诊断仪检
测阴茎海绵体阴茎深动脉，测量血流参数。结果：１３９２例患者中阳性反应者１０３９例，阴性...
PMEPA1在前列腺癌中的表达及临床意义
前列腺癌 PMEPA1基因 GSTP1基因 实时荧光定量PCR
2010/10/15
目的 探讨一种编码受雄激素诱导的前列腺跨膜蛋白基因——PMEPA1（transmembrane prostate androgen induced RNA）的表达，预测前列腺癌非激素依赖型变化的临床意义。
Influential Factors on Discontinuation of Intrauterine Contraceptive Device
IUD Discontinuation Complications
2009/12/16
Background & Aim: Choosing proper method for contraception can help to reduce prevalence of unwanted pregnancy and unsafe abortions. IUD is one of the most trustable; effective, and long-term contrace...
Quantitative assessment of nocturnal penile tumescence and rigidity in normal men using a home monitor
Quantitative assessment nocturnal penile tumescence rigidity normal men
2009/2/23
Current methods now permit the measurement of nocturnal penile tumescence and rigidity (NPTR) in men with erectile dysfunction. But the relationship of rigidity to tumescence and the changes in rigidi...
Development of transmembrane signaling in the fetal rat Leydig cell
transmembrane signaling fetal rat Leydig cell
2009/2/23
Gonadotropin binding to the adult Leydig cell activates a GTP binding protein that interacts with adenylate cyclase to increase cAMP production within the cell. The increased production of cAMP stim...
Stimulation of the proliferation and differentiation of Leydig cell precursors after the destruction of existing Leydig cells with ethane dimethyl sulphonate（EDS）can take place in the absence of LH
proliferation differentiation Leydig cell precursors
2009/2/23
In hypophysectomized rats, 2 days after the administration of the cytotoxic drug ethane dimethyl sulphonate (EDS), the proliferative activity of Leydig cell precursors increased six-fold. Thus, fact...
The differential effects of the indazole-carboxylic acid derivative, tolnidamine, on Sertoli cell protein secretion
Indazole-carboxylic acids tolnidamine antispermatogenic agents Sertoli cell
2009/2/23
The indazole-carboxylic acid derivative tolnidamine (TOL) has marked antispermatogenic activity in rats. Previous morphological and biochemical studies indicate that Sertoli cells are one of the tar...
Normal gonadal functions and fertility after 23 months of treatment of prepubertal male and female dogs with the GnRh agonist [D-Trp6, des-Gly-NH2(10)]GnRH ethylamide
Normal gonadal functions fertility prepubertal male female dogs
2009/2/23
The GnRH agonist [D-Trp6, des-Gly-NH2(10)]GnRH ethylamide was administered to prepubertal male and female dogs daily for 23 months by subcutaneous injection. During GnRH agonist treatment, plasma ster...
Mechanism of LHRH-stimulated steroidogenesis in rat Leydig cells：lipoxygenase products of arachidonic acid may not be involved
LHRH-stimulated steroidogenesis rat Leydig cells lipoxygenase products arachidonic acid
2009/2/23
Luteinizing hormone releasing hormone agonist, [(imBzl)-DHis6,Pro9,NEt]-LHRH (LHRH-A), caused a two to threefold increase in in vitro testosterone (T) secretion by rat Leydig cells. This LHRH-A-indu...
Human sperm mitochondrial function related to motility：a flow and image cytometric assessment
Human sperm mitochondrial function motility cytometric assessment
2009/2/23
Current evaluation of male fertility, routinely estimated by sperm count, motility, and morphology, provides only crude information about the fertility state of individuals. Both flow and image cyto...