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亚低温对急性辐射损伤小鼠的保护作用及其机制研究
亚低温 急性辐射损伤 保护作用
2015/9/2
探讨亚低温对急性辐射损伤小鼠的辐射防护作用及其机制.方法 105只雄性BALB/c小鼠按随机数字表法分为3组,即单纯照射组、亚低温干预组和健康对照组,每组35只.单纯照射组和亚低温干预组小鼠均接受6 Gy 60Co γ射线单次全身照射,亚低温干预组在照后即刻进行亚低温干预并维持6 h,观察照后1、3、7、14、21和28 d小鼠外周血白细胞数、骨髓有核细胞计数,骨髓病理组织学变化,照后6和24 h...
肺癌细胞中HGF/c-Met信号通路的
异常调控及其靶向药物研究进展
c-Met HGF 靶向药物 肺肿瘤
2014/9/4
c-MET是原癌基因c-MET编码的蛋白产物，是肝细胞生长因子（hepatocyte growth factor, HGF）受体，具有络氨酸激酶活性。c-Met的异常表达与肺癌的发生发展有着密切的关系。HGF与其c-Met受体结合后，活化c-Met酪氨酸激酶活性，能促进多种肿瘤细胞包括肺癌细胞的增殖、新生血管生成及肿瘤侵袭和迁移。针对HGF/c-Met信号转导通路的靶向治疗是目前肺癌治疗的新热点。...
2010—2013年新生儿感染性肺炎病原体分布及耐药性分析
病原体 抗药性 微生物 抗菌药物
2014/9/11
分析某院新生儿感染性肺炎分离的病原体分布及耐药情况。方法对2010年1月—2013年12月该院新生儿科及儿科重症监护室送检的新生儿痰液和气管插管末端采样标本进行培养，对分离菌株进行鉴定和药敏试验。结果共检出病原体3 278株，其中革兰阳性菌1 391株（42.43%），革兰阴性菌1 884株（57.47%），真菌3株(0.09%)。病原体中居前5位的是金黄色葡萄球菌、肺炎克雷伯菌、大肠埃希菌、表皮...
研究 琢 - 黑素细胞刺激素（琢-MSH）及其新型类似物 STY39 对内毒素血症小鼠产生组织因子途径抑制物 （TFPI） 的调节作用。 方法 按随机数字表法将雌性 BALB/c 小鼠分为 8 组， 每组 9 只。 经腹腔注射脂多糖 （LPS） 25 滋g/kg 和 D- 氨基半乳糖 （D-Gal） 100 mg/kg 建立内毒素血症小鼠模型； 对照组给予磷酸盐缓冲液； 实验组于 LPS 刺激后 ...
结直肠癌中microRNA标志物临床诊疗价值的研究进展
早期诊断 预后评估 生物标志物 调控机制
2014/7/16
结直肠癌是最常见的消化道恶性肿瘤，其发生、发展及诊疗、预后已成为当前临床研究关注 的热点。microRNAs (miRNAs) 是一类内源性的、19~25个碱基长度的小分子非编码RNA，在人体生命 活动中具有广泛的调节功能。目前发现，部分miRNAs异常表达与结直肠癌的发生、发展密切相关，提 示miRNAs可作为结直肠癌临床早期诊断及预后评估的特异性新型生物标志物。文章综述了miRNAs作 为结直...
腹外疝围手术期抗菌药物使用调查
围手术期 抗菌药物 预防用药 合理用药
2014/7/14
回顾性调查某院2005年6月—2008年6月323例出院的腹外疝患者抗菌药物使用情况。323例腹外疝手术患者均使用抗菌药物，抗菌药物使用率100.00%，无正规围手术期预防用药病例。抗菌药物平均使用时间为（4.46±2.98） d；单一用药占93.81%，二联用药占5.57%，三联用药占0.62%；使用抗菌药物八大类13个品种，以头孢菌素类最多（主要为第三代）。调查结果显示，该院腹外疝患者围手术期...
An Educational Program for Underserved Middle School Students to Encourage Pursuit of Pharmacy and Other Health Science Careers
diversity minority recruitment youth education community service health disparities
2018/7/13
Objective. To develop and implement an active, hands-on program for underrepresented minority (URM) seventh grade students and to determine if participation in the program increased interest in health...
Assessment of Student Performance and Perceptions of Learning in a Medication Use Evaluation Project
Medication use evaluation medication safety pharmacy informatics
2018/7/12
Objective. To describe and assess student perceptions and performance on a medication use evaluation (MUE) team project.
Design. Following a 1-hour MUE lecture in a 62-student patient safety course, ...
Development of an Antimicrobial Stewardship-based Infectious Diseases Elective that Incorporates Human Patient Simulation Technology
active learning simulation technology antimicrobial stewardship infectious diseases
2018/7/12
Objective. To design an elective for pharmacy students that facilitates antimicrobial stewardship awareness, knowledge, and skill development by solving clinical cases, using human patient simulation ...
Addressing the Academic Gap Between 4-and 6-Year Pharmacy Programs in South Korea
academic gap survey preceptorship transitional program South Korea
2018/7/12
Objective. To address the academic gap (or lack of adequate training and programs) between 4- and 6-year pharmacy programs and suggest methods for reducing this gap and to evaluate pharmacists’ percep...
Use of Virtual Patients in an Advanced Therapeutics Pharmacy Course to Promote Active,Patient-Centered Learning
virtual patients active learning simulation
2018/7/10
Objective. To assess student satisfaction and learning of course objectives following the integration of virtual patient cases designed to promote active, patient-centered learning in an advanced ther...
Analysis of Compounded Pharmaceutical Products to Teach the Importance of Quality in an Applied Pharmaceutics Laboratory Course
compounding analysis pharmaceutics pharmacy practice laboratory
2018/7/4
Objective. To assess the effectiveness of a product-analysis laboratory exercise in teaching students the importance of quality in pharmaceutical compounding.
Design. Second-year pharmacy students (N...
Impact of Student- Versus Instructor-Directed Case Discussions on Student Performance in a Pharmacotherapy Capstone Course
active-learning self-directed learning lifelong learning capstone course pharmacotherapy
2018/7/3
Objective. To evaluate the impact of incorporating student-directed (SD) vs instructor-directed (ID) active learning on student performance in a pharmacotherapy capstone course.
Design. This 9-credit...
“Brown Bag” Simulations to Teach Drug Utilization Review
drug utilization review pharmacy skills laboratory
2018/7/3
Objective. To teach drug utilization review (DUR) skills to pharmacy students and assess their abilities and confidence before and after training.
Design. Profile reviews and online and live drug-uti...
During the past 15 years, the curriculum content for nonprescription medication and self-care therapeutics has expanded significantly. Self-care courses ranging from stand-alone, required courses to t...