搜索结果: 1-15 共查到“国际动态 基础医学”相关记录83条 . 查询时间(0.508 秒)
科学家发现延胡索酸诱导的线粒体相关先天免疫反应新机制
延胡索酸 线粒体 先天免疫反应
2024/1/16
肿瘤是一种由多因素驱动的疾病，不同恶性肿瘤有着共同的基本特征，其中细胞代谢重编程在恶性肿瘤发生发展中扮演重要角色。延胡索酸水化酶（fumarate hydratase，FH）是参与三羧酸循环中的代谢酶，被认为是一种肿瘤抑制因子。FH的突变可以导致延胡索酸盐的异常积累，通过一系列级联反应激活细胞恶性转化和肿瘤进展。近期，来自英国剑桥大学的科研团队在《Nature》上在线发表了题为“Fumarate ...
造血干细胞移植是许多恶性、遗传性或自身免疫性疾病的有效再生疗法。然而，目前人们对移植受者造血重建的了解仍然有限。近期，科学家在《Science Immunology》杂志发表题为“Single-cell dissection of human hematopoietic reconstitution after allogeneic hematopoietic stem cell transpla...
Researchers say we appear to be at the start of a new era for Alzheimer’s treatment. Trial results published in January showed that for the first time a drug has been able to slow the cognitive declin...
Chemists’ technique reveals whether antibodies neutralize SARS-CoV-2（图）
抗体 SARS-CoV-2 Covid-19
2023/6/7
Antibodies that can disarm a virus, known as neutralizing antibodies, are key to the body’s ability to fight off infection. MIT chemists have come up with a new way to identify these neutralizing anti...
科学家揭示情感行为状态的心源性控制
情感行为状态 心源性控制 心率
2024/1/17
情绪状态会影响身体的生理机能。例如，焦虑会导致心脏跳动加快，这是一个自上而下的过程。然而，心率加快是否会反过来诱发焦虑反应尚不清楚。美国斯坦福大学研究团队通过小鼠试验，发现情感状态受心率的影响。该研究成果于近日发表在《Nature》杂志上，题为：Cardiogenic control of affective behavioural state。
The immune system does battle in the intestines to keep bacteria in check（图）
Research Infectious Diseases Veterinary Medicine
2023/6/29
Yersinia bacteria cause a variety of human and animal diseases, the most notorious being the plague, caused by Yersinia pestis. A relative, Yersinia pseudotuberculosis, causes gastrointestinal illness...
It’s been known for decades that astronauts’ immune systems become suppressed in space, leaving them vulnerable to disease, but the exact mechanisms of immune dysfunction have remained a mystery – now...
Implantable devices that release insulin into the body hold promise as an alternative way to treat diabetes without insulin injections or cannula insertions.
工业革命以来，化石燃料燃烧和农业化肥使用等人类活动导致大气氮沉降增加。持续的氮输入会显著改变陆地生态系统结构和功能。作为表征微生物生理代谢的重要指标，土壤微生物碳利用效率（CUE）决定着微生物将吸收的碳分配至其生长和呼吸的比例，在很大程度上调控着氮输入背景下的土壤碳固持与分解过程。因此，阐明土壤微生物CUE对氮富集的响应机制是准确预测氮输入背景下土壤碳动态的前提。以往的研究主要关注氮输入引起的土壤...
The immune system remembers. Often this memory, primed by past encounters with threats like bacteria or viruses, is an asset. But when that memory is sparked by internal drivers, like chronic inflamma...
Checkpoint inhibitors have become important tools in the cancer-fighting arsenal. By blocking proteins that normally restrain the immune response, these drugs can help the immune system destroy cancer...
Immunotherapy is a promising strategy to treat cancer by stimulating the body’s own immune system to destroy tumor cells, but it only works for a handful of cancers. MIT researchers have now discovere...
Massages feel good, but do they actually speed muscle recovery? Turns out, they do. Scientists at the Wyss Institute and Harvard John A. Paulson School of Engineering and Applied Sciences applied prec...
The gut microbiome is a diverse environment, jam-packed with up to 1,000 different species of bacteria. Human populations around the globe have significant differences in the composition of their gut ...
《PLoS遗传学》：首次发现汉族特有II型糖尿病致病基因
汉族 II型糖尿病
2010/3/2
来自台湾中央研究院国家基因型鉴定中心，台湾中国医药大学，台湾大学医学院等处的研究人员发现了汉族人特有的II型糖尿病致病基因，这项创新的研究成果不仅可增进对于II型糖尿病致病机制之了解，未来亦有助于糖尿病新药的设计与开发。这一研究成果公布在2010年2月19日国际重要专业期刊《公共科学图书馆·遗传学》（PLoS Genetics）上。